Clinical evidence

Real-world walking. Measured and published.

Researchers are studying how Trexo fits into daily life and rehabilitation: how much people use it, the activity it enables during use, the goals families work toward, and the practical experience of walking at home, at school and in clinics.

171

participants enrolled

Six months of home and community use.

Researchers followed 171 children and young adults whose families had obtained a Trexo, tracking device use month by month and parent-reported outcomes over six months.

Observational cohort · 171 enrolled

Hilderley et al., 2025 · J NeuroEng Rehabil

150

min/week, median

Regular walking in a family-led program.

Fifteen completers in a 12-week program walked a median 150 minutes and five sessions per week. Eight of the 15 met the weekly target on average.

Single-group feasibility study · 19 enrolled, 15 completed

Youngblood et al., 2026 · Disabil Rehabil

99%

of walking time, median

Activity measured during a session.

In 15 participants, a median 99% of robotic walking time met the study’s heart-rate threshold for physical activity, consistent with at least light activity.

Single-session study · 15 participants · activity measured during use

Youngblood et al., 2025 · J Phys Act Health

Research scope: These are feasibility, observational, single-group and qualitative studies, the standard designs in pediatric rehabilitation research. They evaluated Trexo Home and Trexo Plus, and some participants had diagnoses other than cerebral palsy. Full participant details are in each paper. Individual results vary.

01 · Research library

Published Trexo findings

Research on daily use, physical activity, therapy goals and family experience. Each report answers a different question.

  1. Hilderley et al.

    2025

    Six months of home and community robotic walking

    Observational cohort · Journal of NeuroEngineering and Rehabilitation

    Participants: 171 children and young adults enrolled, 70.8% with cerebral palsy; 98 returned six-month questionnaires and 91 had paired mobility scores.

    Setting: Trexo robotic walker used at home and in the community, with families directing their own use over six months.

    Findings: Parents reported statistically significant improvements over six months in functional mobility, physical activity and sleep disturbance. Among the 91 participants with paired mobility scores, seven improved by at least two levels, and median sleep disturbance moved from the moderate to the mild category. Monthly walking minutes and steps held steady while sessions per month decreased.

  2. Youngblood et al.

    2026

    RoWaCaWa: a family-led walking program

    Single-group feasibility study · Disability and Rehabilitation

    Participants: 19 enrolled, 15 completed; 10 completers had cerebral palsy.

    Setting: Trexo robotic walker loaned for home and community use over 12 weeks. Registered as NCT05473676.

    Findings: Completers walked a median 150 minutes, 7,544 steps and five sessions per week, and eight of 15 met the weekly walking target on average. Parent-rated performance of, and satisfaction with, individual goals increased significantly (both p≤0.001). Quality-of-life questionnaires (EQ-5D-Y, Carer-QoL, CP-CHILD) did not change significantly.

    Safety: Walking-related events were mostly skin irritation, including one blister.

    Methods and follow-up details (preprint)
  3. Youngblood et al.

    2025

    Physical activity during a single robotic walking session

    Single-session study · Journal of Physical Activity and Health

    Participants: 15 participants who could not walk independently.

    Setting: One robotic walking session in a Trexo, with heart rate measured throughout.

    Findings: Participants spent a median 17 minutes physically active during the session. A median 99% of walking time exceeded the study’s activity threshold of 20% heart-rate reserve (interquartile range 57–100%). Median session-average intensity was 30% heart-rate reserve, consistent with at least light physical activity.

  4. Bradley, Chau, Kawamura & Wright

    2026

    Exoskeleton-assisted physiotherapy in school and outpatient contexts

    Single-group feasibility study · Developmental Medicine & Child Neurology

    Participants: 10 children with cerebral palsy, GMFCS level IV.

    Setting: Trexo Plus twice weekly for six weeks in school and outpatient settings, delivered by a two-person physiotherapy team. Registered as NCT05463211.

    Findings: All 10 children completed the program, and 15 of 16 clinical feasibility indicators were met. Individual COPM and GAS goals were achieved overall. In their usual supported-stepping walkers, maneuverability improved and therapist assistance decreased in the nine children assessed. Group-level GMFM-88 (mean change +1.0) and one-minute walk distance did not change meaningfully. Children rated comfort positively in 104 of 120 sessions and enjoyment positively in 263 of 312 activities.

    Safety: Skin or muscle discomfort was documented in 13 of 120 sessions and was temporary in 11.

    Registered protocol: NCT05463211
  5. Diot et al.

    2023

    Trexo Home: users, usage and initial impacts

    Observational cohort · Children

    Participants: 70 consented, 66 with usage data and 42 with paired outcomes; 83% with cerebral palsy. These families are also part of the six-month Hilderley cohort above.

    Setting: First month of Trexo Home use, directed by families at home.

    Findings: Families used Trexo Home a median three times a week, taking 732 steps weekly. Parent-reported sleep disturbance decreased significantly (p=0.0066) within the first month. Bowel function, positive affect and physical activity did not change significantly over this short window.

  6. Youngblood, Hilderley & Condliffe

    2026

    Families’ experiences of a robotic walker at home

    Qualitative interviews · Disability and Rehabilitation: Assistive Technology

    Participants: Seven parents whose children had used Trexo at home for at least six months; six children had cerebral palsy.

    Setting: Interviews with families recruited from the home-use research population above.

    Findings: Parents described bonding, enjoyment and new ways for siblings and parents to interact with their child, along with physical changes they noticed. Many described less stress because walking could fit around family life; transfers, transport and cost were the practical challenges raised.

    Qualitative findings (preprint)
  7. Dierwechter & Kolakowsky-Hayner

    2024

    Journey to one million steps in an outpatient clinic

    Implementation report and retrospective case series · Pediatric Physical Therapy

    Participants: 36 children in an outpatient pediatric program, with three case narratives (two with cerebral palsy, one with holoprosencephaly and developmental delay).

    Setting: Trexo Plus at Good Shepherd Rehabilitation Network, Pennsylvania, over about 27 months alongside concurrent therapy.

    Findings: The clinic accumulated one million cumulative Trexo Plus steps across the 36 children. The report describes how staff training, preparation and collaboration with device engineers helped integrate the device into routine therapy. The three cases describe tolerance, stepping practice and progress toward selected therapy goals.

02 · Research library

Study plans and registrations

Protocols explain the questions, methods and outcomes researchers plan to study.

  1. McCormick et al.

    2023

    Comparing robotic gait training and functional clinical therapy

    Published protocol · Contemporary Clinical Trials

    Participants: Planned enrolment of 10 children with cerebral palsy, GMFCS levels III–IV.

    Setting: CHEO / University of Ottawa; randomized crossover feasibility design comparing eight-week periods of Trexo Plus training and functional clinical therapy. Registered as NCT05378243.

    Findings: The protocol combines measures of feasibility, gait and individual goals with family and therapist experience. It is a study plan, not a report of outcomes; results have not yet been published.

    Registry: NCT05378243

03 · Research library

Conference research

Early findings presented at scientific meetings, kept separate from full journal reports.

  1. Landwehr-Prakel et al.

    2025

    Cardiovascular load during walker-based exoskeleton use

    Conference paper · RESNA Annual Conference

    Participants: Four children with cerebral palsy, GMFCS levels III–V.

    Setting: Up to six Trexo visits at the University of Washington, with heart rate recorded. Related registration: NCT05520359.

    Findings: Heart rate rose above resting levels in every measured session. Three of four participants reached peak heart-rate levels classified as moderate or vigorous intensity, measured as the highest 10-second average within a session.

  2. Sisodiya et al.

    2025

    Caregiver priorities for mobility and participation

    Conference poster · APTA CSM #3362

    Participants: Five caregivers of children with cerebral palsy, GMFCS levels III–V, from the same University of Washington program as the RESNA paper above.

    Setting: Interviews after up to six in-lab Trexo sessions.

    Findings: Caregivers described enjoyment, exploration and perceived autonomy during supported movement. Their priorities included participation and inclusion, alongside practical access to technology. Cost, device size, setup assistance and availability were the barriers they named.

04 · Research library

The wider research field

Research across different exoskeletons provides context, separate from findings about Trexo.

  1. Postol et al.

    2026

    “Stepping forward”: a review of wearable overground exoskeletons

    Field context · Systematic review with meta-analysis

    Participants: 21 studies covering 241 participants with cerebral palsy; the two Trexo reports in the study table involved seven participants.

    Setting: Nine wearable overground exoskeletons; literature search through July 2025.

    Findings: The review reports pooled findings favoring robotic training for walking endurance, balance and speed, and highlights the need for broader measures of participation and user experience. The pooled results combine devices and populations, so they are field-level rather than Trexo-specific.

Discuss the research

Looking for a reference, or planning a study? Our clinical team shares full references and works with research groups on new protocols.